Transactions on Mass-Data Analysis of Images and Signals (ISSN:1868-6451)
Volume 7 - Number 1 - September 2016 - Page 3-12
Extraction Kinetics of Ultrasound-assisted Extraction of Oleanolic Acid from Hedyotis corymbosa
Ming-Chi Wei, Pei-Hui Lin, Show-Jen Hong,Yu-Chiao Yang
Chia Nan University of Pharmacy and Science, The Ohio State University USA, Kaohsiung Medical University Taiwan
Abstract
This study investigated a hyphenated procedure of heat-reflux and ultrasound-assisted extraction (HUAE) to improve the extraction efficiency of classic solvent extraction techniques, such as heat-reflux extraction, to extract oleanolic acid (OA) from Hedyotis corymbosa. The superior yield was achieved at a a mean particle size of 0.355 mm, a duty cycle of 75%, a liquid/solid ratio of 12 mL/g, an ethanol concentration of 80% and with extraction temperatures of 56 °C. Compared with heat-reflux extraction method, the HUAE technique reduced the extraction time, extraction temperature and solvent consumption and afforded a higher extraction yield of the target compound from the plant matrix. A second-order kinetic model described the extraction process under different extraction temperatures and showed good agreement with the experimental results.
Keywords: Hedyotis corymbosa, oleanolic acid, heat-reflux extraction, ultrasound-assisted extraction
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